All About Cancer

Normal Cells vs. Tumor Cells by Lisa Ginger

Tumor cells vary from normal cells in several basic ways. First, the division of normal cells is tightly regulated by special cell signals. With tumor cells, it’s as if the signals are no longer produced or perhaps they are no longer received.

Research involving cells is often accomplished by removing the cells from an individual and growing them in a sterile dish with the nutrients required for their survival. Growing cells for research use is termed “cell culture”. Just by watching normal cells in cell culture it is obvious that their division is regulated by something. Normal cells in culture grow until the bottom of their dish is carpeted with the cell. The layer is only 1 cell thick. Once this density is reached, they stop dividing because there is no more space. If one cell dies, an adjacent one will divide to fill in the space. Additionally, normal cells will divide a certain number of times after which time, the division process halts. There are a certain pre-determined number of generations that may be produced and then there is no more dividing. Eventually, the entire culture will die.

With tumor cells, it’s a completely different story. Tumor cells will divide over and over, time after time; forever if supplied with nutrients. With enough time, tumor cells in culture will become a piled up mess. They lack order to their growth. It is as though tumor cells lose have lost the capacity to follow the rules and they divide (proliferate) out of control.

A second major difference between normal cells and tumor cells is that normal cells perform a special function or duty for the body. Healthy cells have specialized behaviors and serve a purpose. For example, lung cells have a specialized duty to perform while cells of cardiac tissue have a very different one. Normal cells taken from different tissues even have very different appearances. Tumor cells have a different appearance than normal cells taken from the tissue they are derived from. This is due to the fact that they have lost their specialized function.

Differentiation is the term given to describe the specialized function a given cell has. Differentiation and proliferation are closely tied together. In general, a cell that proliferates at a high rate loses some of its specialized function. The problem is, it really doesn’t have time to perform a specific function since its too busy dividing. Cells that perform a highly specific function (i.e. differentiated) have a lower rate of proliferation. Researchers are studying the possibility of making tumor/cancer cells differentiated so they might lose their ability to proliferate continuously. In theory, this would cause the tumor to stop growing.
About the Author

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Cancer- The Real Facts by Lisa Hyde

Cancer has a fearsome reputation. Not without reason either. It is a disease that has not yet fully yielded to the skills and intelligence of medical scientists and doctors. And, as if the pain from the disease is not enough, the treatment for cancer, too, inflicts heavy suffering on the body.

Cancer is a disease characterized by uncontrolled and abnormal cell division. Cancer spreads in the body and destroys tissues when the cancer cells travel through the blood stream or the lymphatic system. The runaway growth of cells is caused by mutations to the DNA in the cells that makes the cells unable to control cell division. This mutation can either be inherited or acquired. The mortality rate in cancer depends on the type of cancer and where it develops.

Among cancers, lung cancer is the biggest killer, causing up to 3 million deaths every year worldwide. It affects the above-50 age group population most and is one of the most common types of cancers that occur in the Western countries. The main risk factor for lung cancer is smoking. Cigarette smoke, especially, contains several carcinogens. It is estimated that 80 per cent of all lung cancers are caused by smoking. The role of passive smoking in causing lung cancer is also being recognized by studies.

Another carcinogen that causes lung cancer is asbestos. This substance, which is widely used because of its fire-resistant qualities, causes a rare type of cancer called mesothelioma cancer. In mesothelioma asbestos lung cancer or asbestos cancer, malignant cells develop in the pleura, the outer lining of the lungs and the chest cavity.

The problem with asbestos cancer is that diagnosis is difficult. For one, the symptoms of mesothelioma cancer occur only 30-50 years after the exposure to asbestos. Second, the symptoms of asbestos lung cancer, such as shortness of breath and chest pain, are similar to those of many other medical conditions.

The incidence of mesothelioma asbestos lung cancer has increased in the last two decades. Still it is considered a relatively rare form of lung cancer, because the incidence rate is only 1 per 1,000,000 people. This could be as high as 7-40 per 1,000,000 in the industrialized nations. By contrast, the incidence of lung cancer is 1,000 per 1,000,000.

The common lung cancer treatments include surgery, chemotherapy, and radiation therapy. However, the conventional treatment methods have not been very successful in the case of asbestos cancer, yielding only a median survival rate of 6-12 months after the presentation.

Again, surgery does not have much effect on small-cell lung cancer. A treatment method for lung cancer that has become increasingly popular in recent years is radiofrequency ablation. This technique is especially effective in destroying the cancerous cells inside the tumors. These cells are ‘cooked’ by inserting a small heat probe into the tumor. This technique is also non-toxic and causes very little pain for the patient.

However, there is hope for the cancer-affected. Scientists are developing new techniques of treatment, such as molecular targeted therapies, for lung cancer. Better and more effective therapies can be expected as scientists and researchers coax out more secrets from the human cells.
About the Author

Lisa Hyde-Barrett, a registered nurse and wellness advocate, understands the relationship between awareness and prevention and make breast cancer awareness a top goal! Please visit her site: http://www.support-cancer-awareness.com